Unlocking cryptic genes with a tRNA molecule
The majority of biosynthetic genes are not expressed in a given Streptomcyes strain, which can thwart the discovery of the encoded molecule. There are many factors that can cause such genes to be in a ‘cryptic’ state. We hypothesized that TTA codons, which tend to concentrate in biosynthetic genes, might be one such factor. In collaboration with the … More Unlocking cryptic genes with a tRNA molecule