Sophia-Klara Gassenschmidt from the University of Freiburg will be hanging out in the Zechel lab for 5 weeks to get some experience in enzyme catalysis and natural product biosynthesis. Welcome Sophia!
DLZ had the privilege of being the keynote speaker to open the 8th annual Marine Natural Products Conference at Dalhousie University (August 15th-17th). This is a grad student focused meeting that is held by the East Coast natural products community. Many thanks to David Jakeman of Dalhousie for the invitation to participate in this fantastic meeting.
DLZ and recent MSc graduate Jacqueline Séguin are pleased to announce that their invited review on PhnZ is now published in the Encyclopedia of Inorganic and Bioinorganic Chemistry! A PDF copy of this chapter is available in our publication list.
The Zechel lab is the grateful recipient of an NSERC Discovery Grant worth $300,000 over 5 years! This was awarded to our grant proposal entitled “From Genes to Molecules: Mining Microbial Genomes for New Enzyme Reactions”. We are equally excited that our proposal was one of the few to be selected for a Discovery Accelerator Supplement worth… More NSERC invests in Zechel lab
The Zechel lab had a busy Winter term and is enjoying the transition to summer. A quick review of the past few months: DLZ had the privilege of visiting Trent University for a seminar in March. Many thanks to Steven Rafferty for the invitation and kind hospitality! Fourth year honour students Jessie Hebbert and Akpevweoghene… More An update…..
DLZ had the privilege of giving a seminar to the Department of Chemistry and Biochemistry at WLU on January 29th. Many thanks to Prof. Geoff Horsmann, a fellow traveller in phosphonate biochemistry, for organizing a great visit and the opportunity to tour a wonderful multidisciplinary department.
Congratulations to MSc student Kaitlyn, who is the happy recipient of an Ontario-Baden-Württemburg student exchange award! This award will allow Kaitlyn to visit the lab of Prof. Andreas Bechthold at the Albert-Ludwigs-Universität in Freiburg, Germany, this summer, where she will investigate the biosynthesis of nucleocidin.
In December of 2015 DLZ had the privilege of giving a seminar on nucleocidin biosynthesis in the Natural Product Biosynthesis symposium of Pacifichem (Waikiki, Hawaii). This was a very well attended symposium featuring many of the top international researchers in natural products research. Many thanks to the organizers Bradley Moore (Scripps, UCSD), Ikuro Abe (U. Tokyo), and… More DLZ attends Pacifichem 2015
Is it possible to predict and find a natural product based on a DNA sequence of the producing organism? Since genome sequencing exploded in the early 2000’s, this has been a dream goal of natural product chemists. We teamed up with the Magarvey lab (McMaster University) to use their new Genomes-to-Natural-Products platform (GNP) to link a… More Genes to molecules: the future is now!
Our longtime collaborator Bjarne Hove-Jensen was part of a team from Aarhus University and Cambridge that succeeded in solving the X-ray crystal structure of CP-lyase, a multi-protein complex weighing in at 240 kDa! This is a feat on par with solving the structure of the ribosome or fatty acid synthase. This is an astonishing enzyme system… More The 3-dimensional structure of carbon-phosphorus lyase